Mitochondrial dysfunction and mitophagy in Parkinson’s disease: From mechanism to therapy

Mitochondrial dysfunction and mitophagy in Parkinson’s disease: From mechanism to therapy

Mitochondrial dysfunction is implicated in PD through both environmental exposure and genetic factors. Increased understanding of mitochondrial dysfunction and mitophagy in PD has identified new mechanisms and therapeutic opportunities. Identification of the up- and downstream regulators of PINK1/pa...

Descripció completa

Dades bibliogràfiques
Autors principals:	Malpartida, AB, Williamson, M, Narendra, DP, Wade-Martins, R, Ryan, BJ
Format:	Journal article
Idioma:	English
Publicat:	Cell Press 2020

Ítems similars

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
per: Ryan, B, et al.
Publicat: (2015)

Mitochondrial dysfunction and mitophagy in ADHD: Cellular and molecular mechanisms
per: Mohammed M. Almutairi, et al.
Publicat: (2024-12-01)

Mitochondrial Dynamics and Mitophagy in the 6-Hydroxydopamine Preclinical Model of Parkinson's Disease
per: Maria F. Galindo, et al.
Publicat: (2012-01-01)

Mitochondrial Dysfunction in Parkinson's Disease
per: P. C. Keane, et al.
Publicat: (2011-01-01)

Modulating mitophagy in mitochondrial disease.
per: Dombi, E, et al.
Publicat: (2017)

Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection
per: Ross B. Mounsey, et al.
Publicat: (2011-01-01)

Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease
per: Alexander Blagov, et al.
Publicat: (2024-01-01)

Detecting mitophagy in mitochondrial disease: towards a new type of therapy
per: Dombi, E
Publicat: (2019)

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
per: Smith, A, et al.
Publicat: (2018)

The role of astrocyte dysfunction in Parkinson's disease pathogenesis
per: Booth, H, et al.
Publicat: (2017)

Influence of aging, mitochondrial dysfunction, and inflammation on Parkinson’s disease
per: Davide Cossu, et al.
Publicat: (2024-01-01)

Mitochondrial dysfunction: mechanisms and advances in therapy
per: Yao Zong, et al.
Publicat: (2024-05-01)

Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy
per: Michael Aschner, et al.
Publicat: (2024-12-01)

Diversity in the Regulation of Autophagy and Mitophagy: Lessons from Parkinson's Disease
per: Charleen T. Chu
Publicat: (2011-01-01)

Inflammation and mitophagy are mitochondrial checkpoints to aging
per: Emma Guilbaud, et al.
Publicat: (2024-04-01)

A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease
per: Yongjiang Zhang, et al.
Publicat: (2024-01-01)

αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson’s Disease?
per: David Protter, et al.
Publicat: (2012-01-01)

The role of mitochondrial biogenesis, mitochondrial dynamics and mitophagy in gastrointestinal tumors
per: Yihong Liu, et al.
Publicat: (2025-02-01)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?
per: Michela Zaltieri, et al.
Publicat: (2015-01-01)

Potential Applications of Mitochondrial Therapy with a Focus on Parkinson’s Disease and Mitochondrial Transplantation
per: Pranay Wal, et al.
Publicat: (2024-03-01)

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
per: Ryan, B, et al.
Publicat: (2014)

Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation
per: Dandan Liu, et al.
Publicat: (2024-08-01)

Roles of Mitochondrial Dysfunction in Diabetic Kidney Disease: New Perspectives from Mechanism to Therapy
per: Yichen Yang, et al.
Publicat: (2024-06-01)

Targeting alpha-synuclein as a therapy for Parkinson’s disease
per: Fields, CR, et al.
Publicat: (2019)

Mitophagy plays a central role in mitochondrial ageing
per: Diot, A, et al.
Publicat: (2016)

Mitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategy
per: Foo, Aaron Song Chuan, et al.
Publicat: (2021)

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease
per: Kemal Ugur Tufekci, et al.
Publicat: (2011-01-01)

Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease
per: Enrico Desideri, et al.
Publicat: (2012-01-01)

Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury
per: Jiaying Li, et al.
Publicat: (2025-02-01)

The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights
per: Yuhang Lei, et al.
Publicat: (2024-04-01)

Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases
per: Songling Tang, et al.
Publicat: (2024-07-01)

Investigating the effects of autophagic perturbations on mitochondrial function in Parkinson’s Disease
per: Ryan Barlow Patterson
Publicat: (2019)

Mitochondrial dysfunction and energy changes of black-substance neurons in experimental parkinson's disease in rats and mothors
per: N. M. Buchakchyiska, et al.
Publicat: (2021-09-01)

Binding of α-synuclein to ACO2 promotes progressive mitochondrial dysfunction in Parkinson's disease models
per: Jie Jiao, et al.
Publicat: (2024-11-01)

The effect of training on mitochondrial mitophagy factors in obese male rats
per: Mozhgan Ahmadi, et al.
Publicat: (2022-04-01)

In vivo Mitophagy Monitoring in Caenorhabditis elegans to Determine Mitochondrial Homeostasis
per: Konstantinos Palikaras, et al.
Publicat: (2017-04-01)

Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonism
per: Tyrique Richardson, et al.
Publicat: (2025-02-01)

Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson’s disease and parkinsonism-dementia of Guam
per: Velmarini Vasquez, et al.
Publicat: (2024-12-01)

SLC5A3 depletion promotes apoptosis by inducing mitochondrial dysfunction and mitophagy in gemcitabine-resistant pancreatic cancer cells
per: Minsoo Kim, et al.
Publicat: (2025-03-01)

Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells
per: Guojin Li, et al.
Publicat: (2024-10-01)