Mitochondrial dysfunction and mitophagy in Parkinson’s disease: From mechanism to therapy

Mitochondrial dysfunction and mitophagy in Parkinson’s disease: From mechanism to therapy

Mitochondrial dysfunction is implicated in PD through both environmental exposure and genetic factors. Increased understanding of mitochondrial dysfunction and mitophagy in PD has identified new mechanisms and therapeutic opportunities. Identification of the up- and downstream regulators of PINK1/pa...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Malpartida, AB, Williamson, M, Narendra, DP, Wade-Martins, R, Ryan, BJ
Materialtyp:	Journal article
Språk:	English
Publicerad:	Cell Press 2020

Liknande verk

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
av: Ryan, B, et al.
Publicerad: (2015)

Mitochondrial dysfunction and mitophagy in ADHD: Cellular and molecular mechanisms
av: Mohammed M. Almutairi, et al.
Publicerad: (2024-12-01)

Mitochondrial Dynamics and Mitophagy in the 6-Hydroxydopamine Preclinical Model of Parkinson's Disease
av: Maria F. Galindo, et al.
Publicerad: (2012-01-01)

Mitochondrial Dysfunction in Parkinson's Disease
av: P. C. Keane, et al.
Publicerad: (2011-01-01)

Modulating mitophagy in mitochondrial disease.
av: Dombi, E, et al.
Publicerad: (2017)

Mitochondrial Dysfunction in Parkinson's Disease: Pathogenesis and Neuroprotection
av: Ross B. Mounsey, et al.
Publicerad: (2011-01-01)

Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease
av: Alexander Blagov, et al.
Publicerad: (2024-01-01)

Detecting mitophagy in mitochondrial disease: towards a new type of therapy
av: Dombi, E
Publicerad: (2019)

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
av: Smith, A, et al.
Publicerad: (2018)

The role of astrocyte dysfunction in Parkinson's disease pathogenesis
av: Booth, H, et al.
Publicerad: (2017)

Influence of aging, mitochondrial dysfunction, and inflammation on Parkinson’s disease
av: Davide Cossu, et al.
Publicerad: (2024-01-01)

Mitochondrial dysfunction: mechanisms and advances in therapy
av: Yao Zong, et al.
Publicerad: (2024-05-01)

Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy
av: Michael Aschner, et al.
Publicerad: (2024-12-01)

Diversity in the Regulation of Autophagy and Mitophagy: Lessons from Parkinson's Disease
av: Charleen T. Chu
Publicerad: (2011-01-01)

Inflammation and mitophagy are mitochondrial checkpoints to aging
av: Emma Guilbaud, et al.
Publicerad: (2024-04-01)

A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease
av: Yongjiang Zhang, et al.
Publicerad: (2024-01-01)

αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson’s Disease?
av: David Protter, et al.
Publicerad: (2012-01-01)

The role of mitochondrial biogenesis, mitochondrial dynamics and mitophagy in gastrointestinal tumors
av: Yihong Liu, et al.
Publicerad: (2025-02-01)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?
av: Michela Zaltieri, et al.
Publicerad: (2015-01-01)

Potential Applications of Mitochondrial Therapy with a Focus on Parkinson’s Disease and Mitochondrial Transplantation
av: Pranay Wal, et al.
Publicerad: (2024-03-01)

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
av: Ryan, B, et al.
Publicerad: (2014)

Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation
av: Dandan Liu, et al.
Publicerad: (2024-08-01)

Roles of Mitochondrial Dysfunction in Diabetic Kidney Disease: New Perspectives from Mechanism to Therapy
av: Yichen Yang, et al.
Publicerad: (2024-06-01)

Targeting alpha-synuclein as a therapy for Parkinson’s disease
av: Fields, CR, et al.
Publicerad: (2019)

Mitophagy plays a central role in mitochondrial ageing
av: Diot, A, et al.
Publicerad: (2016)

Mitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategy
av: Foo, Aaron Song Chuan, et al.
Publicerad: (2021)

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease
av: Kemal Ugur Tufekci, et al.
Publicerad: (2011-01-01)

Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease
av: Enrico Desideri, et al.
Publicerad: (2012-01-01)

Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury
av: Jiaying Li, et al.
Publicerad: (2025-02-01)

The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights
av: Yuhang Lei, et al.
Publicerad: (2024-04-01)

Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases
av: Songling Tang, et al.
Publicerad: (2024-07-01)

Investigating the effects of autophagic perturbations on mitochondrial function in Parkinson’s Disease
av: Ryan Barlow Patterson
Publicerad: (2019)

Mitochondrial dysfunction and energy changes of black-substance neurons in experimental parkinson's disease in rats and mothors
av: N. M. Buchakchyiska, et al.
Publicerad: (2021-09-01)

Binding of α-synuclein to ACO2 promotes progressive mitochondrial dysfunction in Parkinson's disease models
av: Jie Jiao, et al.
Publicerad: (2024-11-01)

The effect of training on mitochondrial mitophagy factors in obese male rats
av: Mozhgan Ahmadi, et al.
Publicerad: (2022-04-01)

In vivo Mitophagy Monitoring in Caenorhabditis elegans to Determine Mitochondrial Homeostasis
av: Konstantinos Palikaras, et al.
Publicerad: (2017-04-01)

Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonism
av: Tyrique Richardson, et al.
Publicerad: (2025-02-01)

Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson’s disease and parkinsonism-dementia of Guam
av: Velmarini Vasquez, et al.
Publicerad: (2024-12-01)

SLC5A3 depletion promotes apoptosis by inducing mitochondrial dysfunction and mitophagy in gemcitabine-resistant pancreatic cancer cells
av: Minsoo Kim, et al.
Publicerad: (2025-03-01)

Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells
av: Guojin Li, et al.
Publicerad: (2024-10-01)