Multiscale simulations suggest a mechanism for integrin inside-out activation.
Integrins are large cell-surface adhesion receptors that can be activated to a high affinity state by the formation of an intracellular complex between the integrin β-subunit tail, the membrane, and talin. The F2 and F3 subdomains of the talin head play a key role in formation of this complex. Here,...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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