MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক:	Hogan, J, Deprele, S, Kashemirov, B, Barnett, B, Evdokimov, A, Dunford, J, Russell, R, Ebetino, F, McKenna, C
বিন্যাস:	Journal article
প্রকাশিত:	2007

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2008)

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2007)

The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2008)

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase
অনুযায়ী: Kwassi, A, অন্যান্য
প্রকাশিত: (2009)

Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2006)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2007)

The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2008)

Molecular interactions of nitrogen-containing bisphosphonates within farnesyl diphosphate synthase
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2005)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2006)

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates
অনুযায়ী: Evdokimov, A, অন্যান্য
প্রকাশিত: (2006)

Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2008)

Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2008)

Modeling of bisphosphonate binding to farnesyl diphosphate synthase
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2002)

Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
অনুযায়ী: Xia, Z, অন্যান্য
প্রকাশিত: (2006)

Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2007)

Stereochemical evidence of the mode of binding of nitrogen containing bisphosphonates in farnesyl diphosphate synthase
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2007)

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2008)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2006)

Nitrogen-containing bisphosphonates of varying antiresorptive potency have been co-crystallized in farnesyl diphosphate synthase and modelled to understand the key structural features involved in enzyme inhibition.
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2006)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
অনুযায়ী: Xia, Z, অন্যান্য
প্রকাশিত: (2007)

Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues
অনুযায়ী: Tsoumpra, M, অন্যান্য
প্রকাশিত: (2010)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
অনুযায়ী: Tsoumpra, M, অন্যান্য
প্রকাশিত: (2015)

Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
অনুযায়ী: Lundy, M, অন্যান্য
প্রকাশিত: (2007)

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates
অনুযায়ী: Dunford, J, অন্যান্য
প্রকাশিত: (2006)

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
অনুযায়ী: Tsoumpra, MK, অন্যান্য
প্রকাশিত: (2015)

Molecular modeling of the bisphosphonates (BPs) in farnesyl diphosphate (FPP) synthase. Proposed new mechanism of inhibition by potent nitrogen containing bisphosphonates (NBPs).
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2002)

Molecular modeling of the bisphosphonates in farnesyl diphosphate synthase. potential new details of the precise biochemical mechanism of action of potent nitrogen containing bisphosphonates
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2002)

Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.
অনুযায়ী: Kavanagh, K, অন্যান্য
প্রকাশিত: (2005)

New anti-candida active nitrogen-containing bisphosphonates as inhibitors of farnesyl pyrophosphate synthase Candida albicans
অনুযায়ী: L. O. Metelytsia, অন্যান্য
প্রকাশিত: (2019-05-01)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
অনুযায়ী: Räikkönen, J, অন্যান্য
প্রকাশিত: (2011)

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
অনুযায়ী: Räikkönen, J, অন্যান্য
প্রকাশিত: (2011)

Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
অনুযায়ী: Saman Salari, অন্যান্য
প্রকাশিত: (2024-08-01)

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii.
অনুযায়ী: Yu-Jun Zhao, অন্যান্য
প্রকাশিত: (2015-01-01)

Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the synthesis of isoprenoid precursors.
অনুযায়ী: Jennifer Alcaíno, অন্যান্য
প্রকাশিত: (2014-01-01)

The relationship between the chemistry and biological activity of the bisphosphonates.
অনুযায়ী: Ebetino, F, অন্যান্য
প্রকাশিত: (2011)

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase
অনুযায়ী: Kavanagh, K, অন্যান্য
প্রকাশিত: (2006)

Role of the geminal hydroxyl group in target enzyme inhibition by bisphosphonates and phosphonocarboxylates
অনুযায়ী: Stewart, C, অন্যান্য
প্রকাশিত: (2007)

Differential effects of alpha-halogenation on the potency of bisphosphonates and phosphonocarboxylates for inhibition of their target enzymes
অনুযায়ী: Stewart, C, অন্যান্য
প্রকাশিত: (2007)

Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
অনুযায়ী: Marma, MS, অন্যান্য
প্রকাশিত: (2007)

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells
অনুযায়ী: Wei Xu, অন্যান্য
প্রকাশিত: (2024-09-01)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase

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