The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain1,2. Here we uncover a link between these processes...

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Bibliographic Details
Main Authors: Cronin, SJF, Seehus, C, Weidinger, A, Talbot, S, Reissig, S, Seifert, M, Pierson, Y, McNeill, E, Longhi, MS, Turnes, BL, Kreslavsky, T, Kogler, M, Hoffmann, D, Ticevic, M, Da Luz Scheffer, D, Tortola, L, Cikes, D, Jais, A, Rangachari, M, Rao, S, Paolino, M, Novatchkova, M, Aichinger, M, Barrett, L, Latremoliere, A, Wirnsberger, G, Lametschwandtner, G, Busslinger, M, Zicha, S, Latini, A, Robson, SC, Waisman, A, Andrews, N, Costigan, M, Channon, KM, Weiss, G, Kozlov, AV, Tebbe, M, Johnsson, K, Woolf, CJ, Penninger, JM
Format: Journal article
Language:English
Published: Springer Nature 2018

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