The chemistry, physiology and pathology of pH in cancer.
Cell survival is conditional on the maintenance of a favourable acid-base balance (pH). Owing to intensive respiratory CO2 and lactic acid production, cancer cells are exposed continuously to large acid-base fluxes, which would disturb pH if uncorrected. The large cellular reservoir of H(+)-binding...
Main Authors: | Swietach, P, Vaughan-Jones, R, Harris, A, Hulikova, A |
---|---|
Format: | Journal article |
Sprog: | English |
Udgivet: |
2014
|
Lignende værker
-
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
af: Swietach, P, et al.
Udgivet: (2010) -
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation.
af: Swietach, P, et al.
Udgivet: (2010) -
Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.
af: Hulikova, A, et al.
Udgivet: (2013) -
Acid-extrusion from tissue: the interplay between membrane transporters and pH buffers.
af: Hulikova, A, et al.
Udgivet: (2012) -
Intracellular carbonic anhydrase activity sensitizes cancer cell pH signaling to dynamic changes in CO2 partial pressure
af: Hulikova, A, et al.
Udgivet: (2014)