Synthesis and reactivity of novel gamma-phosphate modified ATP analogues.

Synthesis and reactivity of novel gamma-phosphate modified ATP analogues.

We hereby present a simple yet novel chemical synthesis of a family of gamma-modified ATPs bearing functional groups on the gamma-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of th...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Lee, SE, Elphick, L, Anderson, A, Bonnac, L, Child, E, Mann, D, Gouverneur, V
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2009
Govvádus
Čoahkkáigeassu:We hereby present a simple yet novel chemical synthesis of a family of gamma-modified ATPs bearing functional groups on the gamma-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27(kip1) is also presented.

Geahča maid