Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself and in other proteins. Several PARP1 and PARP2 inhibitors are currently employed in the clinic or undergoing trials for treatment of va...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, ML, Ahel, D, Huet, S, Suskiewicz, MJ, Ahel, I
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Springer Nature 2021

Eitemau Tebyg

Progress and outlook in studying the substrate specificities of PARPs and related enzymes
gan: Suskiewicz, MJ, et al.
Cyhoeddwyd: (2020)

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
gan: Bilokapic, S, et al.
Cyhoeddwyd: (2020)

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
gan: Kar, P, et al.
Cyhoeddwyd: (2024)

HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity
gan: Gibbs-Seymour, I, et al.
Cyhoeddwyd: (2016)

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
gan: Suskiewicz, MJ, et al.
Cyhoeddwyd: (2020)

PARP, transcription and chromatin modeling
gan: Posavec Marjanović, M, et al.
Cyhoeddwyd: (2016)

Updated protein domain annotation of the PARP protein family sheds new light on biological function
gan: Suskiewicz, MJ, et al.
Cyhoeddwyd: (2023)

Interplay of histone marks with serine ADP-ribosylation
gan: Bartlett, E, et al.
Cyhoeddwyd: (2018)

The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
gan: Kira Schützenhofer, et al.
Cyhoeddwyd: (2021-11-01)

The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
gan: Jaromir Hunia, et al.
Cyhoeddwyd: (2022-12-01)

Mechanistic insights into the HPF1/PARP1 complex
gan: Zobel, FFH
Cyhoeddwyd: (2021)

The role of PARPs and APLF in DNA interstrand crosslink repair
gan: Zobel, F
Cyhoeddwyd: (2017)

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
gan: Pietro Fontana, et al.
Cyhoeddwyd: (2023-06-01)

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
gan: Prokhorova, E, et al.
Cyhoeddwyd: (2021)

Serine is the major residue for ADP-ribosylation upon DNA damage
gan: Palazzo, L, et al.
Cyhoeddwyd: (2018)

Serine ADP-Ribosylation Depends on HPF1
gan: Bonfiglio, J, et al.
Cyhoeddwyd: (2017)

Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes
gan: Natalya Maluchenko, et al.
Cyhoeddwyd: (2022-10-01)

Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
gan: Tatyana A. Kurgina, et al.
Cyhoeddwyd: (2021-11-01)

Combinations of PARP inhibitors with temozolomide drive PARP1 trapping and apoptosis in Ewing’s sarcoma
gan: Gill, S, et al.
Cyhoeddwyd: (2015)

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential
gan: Rack, JGM, et al.
Cyhoeddwyd: (2020)

Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells
gan: Paulina Gil-Kulik, et al.
Cyhoeddwyd: (2020-05-01)

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry
gan: Isabelle Maxim, et al.
Cyhoeddwyd: (2010-04-01)

Serine is the major residue for ADP-ribosylation upon DNA damage
gan: Luca Palazzo, et al.
Cyhoeddwyd: (2018-02-01)

ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12
gan: Lili Li, et al.
Cyhoeddwyd: (2021-06-01)

PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels
gan: Erbel C, et al.
Cyhoeddwyd: (2011-08-01)

PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib
gan: Xia Ding, et al.
Cyhoeddwyd: (2022-07-01)

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
gan: M. M. Kutuzov, et al.
Cyhoeddwyd: (2021-03-01)

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
gan: Hyoung Kim, et al.
Cyhoeddwyd: (2020-07-01)

Dual Inhibitors of PARPs and ROCKs
gan: Albert A. Antolín, et al.
Cyhoeddwyd: (2018-10-01)

KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer
gan: Zhiyan Zhan, et al.
Cyhoeddwyd: (2024-09-01)

Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods
gan: Hongye Hu, et al.
Cyhoeddwyd: (2020-05-01)

A PARP1-related prognostic signature constructing and PARP-1 inhibitors screening for glioma
gan: Hui Li, et al.
Cyhoeddwyd: (2022-08-01)

Virtual screening for plant PARP inhibitors – what can be learned from human PARP inhibitors?
gan: Heym Peter-Paul, et al.
Cyhoeddwyd: (2012-05-01)

HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer
gan: Hanlin Ma, et al.
Cyhoeddwyd: (2022-03-01)

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
gan: Marco Gatti, et al.
Cyhoeddwyd: (2020-08-01)

Serine ADP-ribosylation reversal by the hydrolase ARH3
gan: Fontana, P, et al.
Cyhoeddwyd: (2017)

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
gan: Zhu, K, et al.
Cyhoeddwyd: (2022)

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage
gan: Zongying Gu, et al.
Cyhoeddwyd: (2019-08-01)

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.
gan: Fenqing Shang, et al.
Cyhoeddwyd: (2016-01-01)

PARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis
gan: Antonio Ginés García-Saura, et al.
Cyhoeddwyd: (2021-03-01)