Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself and in other proteins. Several PARP1 and PARP2 inhibitors are currently employed in the clinic or undergoing trials for treatment of va...

書誌詳細
主要な著者:	Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, ML, Ahel, D, Huet, S, Suskiewicz, MJ, Ahel, I
フォーマット:	Journal article
言語:	English
出版事項:	Springer Nature 2021

類似資料

Progress and outlook in studying the substrate specificities of PARPs and related enzymes
著者:: Suskiewicz, MJ, 等
出版事項: (2020)

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
著者:: Bilokapic, S, 等
出版事項: (2020)

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
著者:: Kar, P, 等
出版事項: (2024)

HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity
著者:: Gibbs-Seymour, I, 等
出版事項: (2016)

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
著者:: Suskiewicz, MJ, 等
出版事項: (2020)

PARP, transcription and chromatin modeling
著者:: Posavec Marjanović, M, 等
出版事項: (2016)

Updated protein domain annotation of the PARP protein family sheds new light on biological function
著者:: Suskiewicz, MJ, 等
出版事項: (2023)

Interplay of histone marks with serine ADP-ribosylation
著者:: Bartlett, E, 等
出版事項: (2018)

The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
著者:: Kira Schützenhofer, 等
出版事項: (2021-11-01)

The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
著者:: Jaromir Hunia, 等
出版事項: (2022-12-01)

Mechanistic insights into the HPF1/PARP1 complex
著者:: Zobel, FFH
出版事項: (2021)

The role of PARPs and APLF in DNA interstrand crosslink repair
著者:: Zobel, F
出版事項: (2017)

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling
著者:: Pietro Fontana, 等
出版事項: (2023-06-01)

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
著者:: Prokhorova, E, 等
出版事項: (2021)

Serine is the major residue for ADP-ribosylation upon DNA damage
著者:: Palazzo, L, 等
出版事項: (2018)

Serine ADP-Ribosylation Depends on HPF1
著者:: Bonfiglio, J, 等
出版事項: (2017)

Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes
著者:: Natalya Maluchenko, 等
出版事項: (2022-10-01)

Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
著者:: Tatyana A. Kurgina, 等
出版事項: (2021-11-01)

Combinations of PARP inhibitors with temozolomide drive PARP1 trapping and apoptosis in Ewing’s sarcoma
著者:: Gill, S, 等
出版事項: (2015)

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential
著者:: Rack, JGM, 等
出版事項: (2020)

Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells
著者:: Paulina Gil-Kulik, 等
出版事項: (2020-05-01)

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry
著者:: Isabelle Maxim, 等
出版事項: (2010-04-01)

Serine is the major residue for ADP-ribosylation upon DNA damage
著者:: Luca Palazzo, 等
出版事項: (2018-02-01)

ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12
著者:: Lili Li, 等
出版事項: (2021-06-01)

PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels
著者:: Erbel C, 等
出版事項: (2011-08-01)

PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib
著者:: Xia Ding, 等
出版事項: (2022-07-01)

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
著者:: M. M. Kutuzov, 等
出版事項: (2021-03-01)

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
著者:: Hyoung Kim, 等
出版事項: (2020-07-01)

Dual Inhibitors of PARPs and ROCKs
著者:: Albert A. Antolín, 等
出版事項: (2018-10-01)

KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer
著者:: Zhiyan Zhan, 等
出版事項: (2024-09-01)

Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods
著者:: Hongye Hu, 等
出版事項: (2020-05-01)

A PARP1-related prognostic signature constructing and PARP-1 inhibitors screening for glioma
著者:: Hui Li, 等
出版事項: (2022-08-01)

Virtual screening for plant PARP inhibitors – what can be learned from human PARP inhibitors?
著者:: Heym Peter-Paul, 等
出版事項: (2012-05-01)

HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer
著者:: Hanlin Ma, 等
出版事項: (2022-03-01)

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
著者:: Marco Gatti, 等
出版事項: (2020-08-01)

Serine ADP-ribosylation reversal by the hydrolase ARH3
著者:: Fontana, P, 等
出版事項: (2017)

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
著者:: Zhu, K, 等
出版事項: (2022)

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage
著者:: Zongying Gu, 等
出版事項: (2019-08-01)

Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade.
著者:: Fenqing Shang, 等
出版事項: (2016-01-01)

PARP10 Multi-Site Auto- and Histone MARylation Visualized by Acid-Urea Gel Electrophoresis
著者:: Antonio Ginés García-Saura, 等
出版事項: (2021-03-01)