Artemether-lumefantrine and dihydroartemisinin-piperaquine exert inverse selective pressure on Plasmodium Falciparum drug sensitivity-associated haplotypes in Uganda
<p>BACKGROUND: Altered sensitivity to multiple antimalarial drugs is mediated by polymorphisms in pfmdr1, which encodes the Plasmodium falciparum multidrug resistance transporter. In Africa the N86Y and D1246Y polymorphisms have been shown to be selected by treatment, with artemether-lumefantr...
| Autores principales: | , , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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