Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies

The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synth...

全面介绍

书目详细资料
Main Authors: Cheung, J, Wand, N, Ooi, C, Ridewood, S, Wheeler, R, Rudenko, G
其他作者: Hill, K
格式: Journal article
出版: Public Library of Science 2016