BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Roberts, T, Etxaniz, U, Dall'Agnese, A, Wu, S, Chiang, C, Brennan, P, Wood, M, Puri, P
Fformat: Journal article
Iaith:English
Cyhoeddwyd: Springer Nature 2017