Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
Background: <em>Plasmodium falciparum</em> readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analo...
| Главные авторы: | , , , , , , |
|---|---|
| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
BioMed Central
2010
|
| Предметы: |
Search Result 1
Computational analysis of binding between malarial dihydrofolate reductases and anti-folates.
Опубликовано 2010
Journal article