Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand.

Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand.

We have used DNase I footprinting to examine the binding of five different 17-mer oligonucleotides to a 53-base oligopurine tract containing four pyrimidine interruptions. Although all the expected triplexes formed with high affinity (K(d) approximately 10-50 nM), one oligonucleotide produced a foot...

Полное описание

Библиографические подробности
Главные авторы:	Fox, K, Flashman, E, Gowers, D
Формат:	Journal article
Язык:	English
Опубликовано:	2000

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