Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand.

Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand.

We have used DNase I footprinting to examine the binding of five different 17-mer oligonucleotides to a 53-base oligopurine tract containing four pyrimidine interruptions. Although all the expected triplexes formed with high affinity (K(d) approximately 10-50 nM), one oligonucleotide produced a foot...

Bibliográfalaš dieđut
Váldodahkkit:	Fox, K, Flashman, E, Gowers, D
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2000

Geahča maid

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Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches.
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Four base recognition by triplex-forming oligonucleotides at physiological pH.
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Oxidative DNA cleavage with clip‐phenanthroline triplex‐forming oligonucleotide hybrids
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DNA triple-helix formation at target sites containing duplex mismatches.
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Formation of stable DNA triplexes.
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DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine.
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The stability of triplex DNA is affected by the stability of the underlying duplex.
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Design and synthesis of fluorogenic oligonucleotide-based systems to target double-stranded DNA
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Almmustuhtton: (1999)

Triplex-directed covalent cross-linking of a DNA nanostructure.
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Almmustuhtton: (2012)

Bulging brains
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Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.
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Recognition of GT mismatches by Vsr mismatch endonuclease.
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Almmustuhtton: (2000)

Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod.
Dahkki: Flashman, E, et al.
Almmustuhtton: (2007)

Solution conformation of an intramolecular DNA triplex containing a nonnucleotide linker: comparison with the DNA duplex.
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Almmustuhtton: (1997)

RNA aptamers binding the double-stranded RNA-binding domain.
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Biophysical studies of oligonucleotides containing duplex stabilising modifications
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