Investigating the function of microtubule-associated protein tau (MAPT) and its genetic association with Parkinson’s using human iPSC-derived dopamine neurons

Investigating the function of microtubule-associated protein tau (MAPT) and its genetic association with Parkinson’s using human iPSC-derived dopamine neurons

<p>Parkinson's disease (PD) primarily manifests as loss of motor control through the degeneration of nigrostriatal dopaminergic neurons. The microtubule-associated protein tau (<em>MAPT</em>) locus is highly genetically associated with PD, wherein the H1 haplotype confers dise...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Beevers, J
Awduron Eraill:	Wade-Martins, R
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2016
Pynciau:	Neurodegeneration Parkinson's disease Induced pluripotent stem cells

Eitemau Tebyg

Studying α-Synuclein pathology using iPSC-derived dopaminergic neurons
gan: Zambon, F
Cyhoeddwyd: (2017)

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes
gan: Heather D.E. Booth, et al.
Cyhoeddwyd: (2019-09-01)

Long-Term Evaluation of Intranigral Transplantation of Human iPSC-Derived Dopamine Neurons in a Parkinson’s Disease Mouse Model
gan: Sébastien Brot, et al.
Cyhoeddwyd: (2022-05-01)

Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients
gan: Rubén Fernández‐Santiago, et al.
Cyhoeddwyd: (2015-10-01)

Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models
gan: Lorenza Mautone, et al.
Cyhoeddwyd: (2025-01-01)

Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease
gan: McGuinness, W
Cyhoeddwyd: (2023)

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice
gan: Mohamed Aghyad Al Kabbani, et al.
Cyhoeddwyd: (2025-08-01)

NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons
gan: Sahar Avazzadeh, et al.
Cyhoeddwyd: (2021-09-01)

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
gan: Imaizumi Yoichi, et al.
Cyhoeddwyd: (2012-10-01)

Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology
gan: Sahar Avazzadeh, et al.
Cyhoeddwyd: (2021-03-01)

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening
gan: Chao Wang, et al.
Cyhoeddwyd: (2017-10-01)

Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson’s Disease
gan: Elissavet Akrioti, et al.
Cyhoeddwyd: (2022-06-01)

Alpha-Synuclein Gene Alterations Modulate Tyrosine Hydroxylase in Human iPSC-Derived Neurons in a Parkinson’s Disease Animal Model
gan: Luis Daniel Bernal-Conde, et al.
Cyhoeddwyd: (2024-06-01)

MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis
gan: Maika Itsuno, et al.
Cyhoeddwyd: (2025-03-01)

Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated with the pathological variant c.2013T>G in the MAPT gene
gan: E. V. Grigor’eva, et al.
Cyhoeddwyd: (2024-11-01)

The EBiSC iPSC bank for disease studies
gan: Rachel Steeg, et al.
Cyhoeddwyd: (2020-12-01)

STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease
gan: Vladimir A. Vigont, et al.
Cyhoeddwyd: (2021-02-01)

iPSC-Derived Biological Pacemaker—From Bench to Bedside
gan: Quan Duy Vo, et al.
Cyhoeddwyd: (2024-12-01)

A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1
gan: Anika V. Prabhu, et al.
Cyhoeddwyd: (2021-10-01)

iPSC-derived cells for whole liver bioengineering
gan: Kayque Alves Telles-Silva, et al.
Cyhoeddwyd: (2024-02-01)

Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease
gan: Fahad Mubariz, et al.
Cyhoeddwyd: (2023-06-01)

Human iPSC banking: barriers and opportunities
gan: Ching-Ying Huang, et al.
Cyhoeddwyd: (2019-10-01)

Regeneration difficulties in patients with FQAD can limit the use of iPSc-based cell therapy
gan: Dagmara Grot, et al.
Cyhoeddwyd: (2022-05-01)

Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the <i>GBA1</i> Gene
gan: Elena S. Yarkova, et al.
Cyhoeddwyd: (2024-03-01)

Enfermedad de Parkinson: actualización de estudios preclínicos con el uso de células troncales pluripotentes inducidas
gan: V. Valadez-Barba, et al.
Cyhoeddwyd: (2023-11-01)

Effect of Honokiol on culture time and survival of Alzheimer’s disease iPSC-derived neurons
gan: Duong Thi Thuy Le, et al.
Cyhoeddwyd: (2024-01-01)

Utility of iPSC-Derived Cells for Disease Modeling, Drug Development, and Cell Therapy
gan: Martin W. Nicholson, et al.
Cyhoeddwyd: (2022-06-01)

Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons
gan: Damien Meng-Kiat Leow, et al.
Cyhoeddwyd: (2024-06-01)

MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons.
gan: Beevers, J, et al.
Cyhoeddwyd: (2017)

Human iPSC-derived glia models for the study of neuroinflammation
gan: Nina Stöberl, et al.
Cyhoeddwyd: (2023-10-01)

Engineering considerations of iPSC-based personalized medicine
gan: Sangbae Park, et al.
Cyhoeddwyd: (2023-07-01)

Phenotyping C9-ALS/FTD iPSC-derived cortical neurons
gan: Graf, MS
Cyhoeddwyd: (2023)

Induced pluripotent stem cell–related approaches to generate dopaminergic neurons for Parkinson’s disease
gan: Ling-Xiao Yi, et al.
Cyhoeddwyd: (2025-11-01)

Suspension culture improves iPSC expansion and pluripotency phenotype
gan: Nerea Cuesta-Gomez, et al.
Cyhoeddwyd: (2023-06-01)

Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations
gan: Iñaki Álvarez, et al.
Cyhoeddwyd: (2023-12-01)

Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons
gan: Guanqun Huang, et al.
Cyhoeddwyd: (2019-03-01)

ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons
gan: Sandra Harjuhaahto, et al.
Cyhoeddwyd: (2020-07-01)

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons
gan: Joel E. Beevers, et al.
Cyhoeddwyd: (2017-08-01)

Quantitative comparison of the mRNA content of human iPSC‐derived motor neurons and their extracellular vesicles
gan: Kentaro Otake, et al.
Cyhoeddwyd: (2021-02-01)

Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue
gan: Célia Raïs, et al.
Cyhoeddwyd: (2023-11-01)