A role for the ITAM signaling module in specifying cytokine-receptor functions

Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear. Here we describe a mechanism for signal integration based on the functional coupling of two distinct signaling pat...

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Bibliographic Details
Main Authors: Bezbradica, J, Rosenstein, R, Demarco, R, Brodsky, I, Medzhitov, R
Format: Journal article
Language:English
Published: Springer Nature 2014