Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life

Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer’s disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2-7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain features...

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Bibliographic Details
Main Authors:	Roe, J, Vidal Pineiro, D, Sørensen, Ø, Grydeland, H, Leonardsen, E, Iakunchykova, O, Pan, M, Mowinckel, A, Strømstad, M, Nawijn, L, Milaneschi, Y, Andersson, M, Pudas, S, Bråthen, AC, Kransberg, J, Falch, E, Øverbye, K, Kievit, R, Ebmeier, KP, Lindenberger, U, Ghisletta, P, Demnitz, N, Boraxbekk, C-J, Drevon, C, Penninx, B, Bertram, L, Nyberg, L, Walhovd, K, Fjell, A, Wang, Y
Other Authors:	Alzheimer‘s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Format:	Journal article
Language:	English
Published:	Springer Nature 2024

Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life

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