SGTx1‚ a Kv channel gating−modifier toxin‚ binds to the interfacial region of lipid bilayers

SGTx1 is a gating-modifier toxin that has been shown to inhibit the voltage-gated potassium channel Kv2.1. SGTx1 is thought to bind to the S3b-S4a region of the voltage-sensor, and is believed to alter the energetics of gating. Gating-modifier toxins such as SGTx1 are of interest as they can be used...

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Autores principales: Wee, C, Bemporad, D, Sands, Z, Gavaghan, D, Sansom, M
Formato: Journal article
Publicado: 2007