Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis).

RATIONALE: α2-Antiplasmin (A2AP) is a major inhibitor of fibrinolysis by virtue of its capacity to inhibit plasmin. Although the fibrinolytic system is strongly affected by infection, the functional role of A2AP in the host response to sepsis is unknown. OBJECTIVES: To study the role of A2AP in meli...

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Bibliographic Details
Main Authors: Kager, L, Weehuizen, T, Wiersinga, W, Roelofs, J, Meijers, J, Dondorp, A, van 't Veer, C, van der Poll, T
Format: Journal article
Language:English
Published: 2013