Thermoresponsive polymer nanoparticles co-deliver RSV F trimers with a TLR-7/8 adjuvant

Thermoresponsive polymer nanoparticles co-deliver RSV F trimers with a TLR-7/8 adjuvant

Structure-based vaccine design has been used to develop immunogens that display conserved neutralization sites on pathogens such as HIV-1, respiratory syncytial virus (RSV), and influenza. Improving the immunogenicity of these designed immunogens with adjuvants will require formulations that do not...

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Detalhes bibliográficos
Main Authors: Francica, JR, Lynn, GM, Laga, R, Joyce, MG, Ruckwardt, TJ, Morabito, KM, Chen, M, Chaudhuri, R, Zhang, B, Sastry, M, Druz, A, Ko, K, Choe, M, Pechar, M, Georgiev, IS, Kueltzo, LA, Seymour, LW, Mascola, JR, Kwong, PD, Graham, BS, Seder, RA
Formato: Journal article
Idioma:English
Publicado em: American Chemical Society 2016

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