Fragment-based identification of ligands for bromodomain-containing factor 3 of Trypanosoma cruzi
The Trypanosoma cruzi (T. cruzi) parasite is the cause of Chagas disease, a neglected disease endemic in South America. The life cycle of the T. cruzi parasite is complex and includes transitions between distinct life stages. This change in phenotype (without a change in genotype) could be controlle...
Main Authors: | Laurin, CMC, Bluck, JP, Chan, AKN, Keller, M, Boczek, A, Scorah, AR, See, KFL, Jennings, LE, Hewings, DS, Woodhouse, F, Reynolds, JK, Schiedel, M, Humphreys, PG, Biggin, PC, Conway, SJ |
---|---|
Format: | Journal article |
Language: | English |
Published: |
American Chemical Society
2020
|
Similar Items
-
Chemical tools to probe the role of bromodomains in the parasite Trypanosoma cruzi
by: Laurin, CMC
Published: (2019) -
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
by: Jennings, L, et al.
Published: (2018) -
Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains
by: Sekirnik, AR, et al.
Published: (2022) -
Controlling intramolecular interactions in the design of selective, high-affinity, ligands for the CREBBP Bromodomain
by: Brand, M, et al.
Published: (2021) -
Developing inhibitors of bromodomain-histone interactions
by: Hewings, D
Published: (2014)