Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly

Nap1 is a histone chaperone involved in the nuclear import of H2A-H2B and nucleosome assembly. Here, we report the crystal structure of Nap1 bound to H2A-H2B together with in vitro and in vivo functional studies that elucidate the principles underlying Nap1-mediated H2A-H2B chaperoning and nucleosom...

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Bibliographic Details
Main Authors: Aguilar-Gurrieri, C, Larabi, A, Vinayachandran, V, Patel, N, Yen, K, Reja, R, Ebong, I, Schoehn, G, Robinson, C, Pugh, B, Panne, D
Format: Journal article
Language:English
Published: EMBO Press 2016