Platelets sequester extracellular DNA, capturing tumour-derived and free foetal DNA

Platelets are small, anucleate cells with important roles in haemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release chromosomal DNA, resulting in ‘cell free’ DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their ability to sense and internalise path...