Simple randomization did not protect against bias in smaller trials

OBJECTIVES: By removing systematic differences across treatment groups, simple randomization is assumed to protect against bias. However, random differences may remain if the sample size is insufficiently large. We sought to determine the minimal sample size required to eliminate random differences,...

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Bibliographic Details
Main Authors: Nguyen, T, Collins, G, Lamy, A, Devereaux, P, Daurès, J, Landais, P, Le Manach, Y
Format: Journal article
Language:English
Published: Elsevier 2017