Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers.

The iminosugar N-butyldeoxynojirimycin (NB-DNJ), an endoplasmic reticulum alpha-glucosidase inhibitor, has an antiviral effect against bovine viral diarrhea virus (BVDV). In this report, we investigate the molecular mechanism of this inhibition by studying the folding pathway of BVDV envelope glycop...

Descripció completa

Dades bibliogràfiques
Autors principals: Branza-Nichita, N, Durantel, D, Carrouée-Durantel, S, Dwek, R, Zitzmann, N
Format: Journal article
Idioma:English
Publicat: American Society for Microbiology 2001