Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

<p>The human 2-oxoglutarate (2OG)- and Fe(<small>II</small>)-dependent oxygenases factor inhibiting hypoxia-inducible factor-α (FIH) and HIF-α prolyl residue hydroxylases 1–3 (PHD1–3) regulate the response to hypoxia in humans <em...

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Bibliographic Details
Main Authors:	Corner, TP, Teo, RZR, Wu, Y, Salah, E, Nakashima, Y, Fiorini, G, Tumber, A, Brasnett, A, Holt-Martyn, JP, Figg, WD, Zhang, X, Brewitz, L, Schofield, CJ
Format:	Journal article
Language:	English
Published:	Royal Society of Chemistry 2023

Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

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