Developing novel blood-stage malaria vaccines

Developing novel blood-stage malaria vaccines

<p>Natural exposure to Plasmodium falciparum’s asexual blood-stage results in protection against severe disease, but no vaccine using the widely-studied blood-stage antigens apical membrane antigen 1 (AMA1) or merozoite surface protein 1 (MSP1) has proven convincingly protective in clinical tr...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Douglas, AD
Awduron Eraill:	Draper, SJ
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2015
Pynciau:	Medical sciences Parasitology Immunology Disease prevention Vaccinology Infectious diseases Malaria

Eitemau Tebyg

Pre-clinical development of viral vectored transmission-blocking malaria vaccines
gan: Kapulu, MC
Cyhoeddwyd: (2014)

Enhancing the efficacy of viral vector blood-stage malaria vaccines
gan: Forbes, E
Cyhoeddwyd: (2011)

Analysis of b cell responses to blood-stage malaria antigens in humans following immunization with candidate vaccines and controlled human malaria infection
gan: Elias, SC
Cyhoeddwyd: (2014)

Liver-stage vaccines for malaria
gan: Longley, RJ
Cyhoeddwyd: (2013)

Malaria pre-erythrocytic stage vaccines: targeting antigen combinations
gan: Bauza, K
Cyhoeddwyd: (2012)

Long term efficacy of a pre-erythrocytic malaria vaccine and correlates of protection in children residing in a malaria endemic country
gan: Olotu, A
Cyhoeddwyd: (2013)

Towards improved blood-stage malaria vaccines: characterising the underlying immunogenicity of vaccine adjuvants and vectors
gan: de Cassan, S
Cyhoeddwyd: (2011)

Transcutaneous delivery of T Cell-inducing viral vector Malaria vaccines by microneedle patches
gan: Pearson, FE
Cyhoeddwyd: (2011)

Hepcidin regulation in Malaria
gan: Spottiswoode, N
Cyhoeddwyd: (2015)

Host genetic factors and vaccine-induced immunity to hepatitis B virus infection
gan: Hennig, B, et al.
Cyhoeddwyd: (2008)

Characterising immune responses to viral vectored vaccines against influenza and hepatitis C
gan: Antrobus, R
Cyhoeddwyd: (2014)

Evaluation of a potential vaccine against hyperinvasive serogroup B Neisseria meningitidis by assessment of the effects of surface-expressed Opacity-associated proteins on the immune system
gan: Sadarangani, M
Cyhoeddwyd: (2011)

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate TB vaccine, MVA85A, alone and in combination
gan: Harris, S, et al.
Cyhoeddwyd: (2013)

Understanding vaccine induced protective immunity to Mycobacterium tuberculosis
gan: Ronan, E
Cyhoeddwyd: (2011)

Understanding the link between interleukin 17 and vaccine-induced protection in tuberculosis
gan: Griffiths, K
Cyhoeddwyd: (2012)

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response.
gan: Matsumiya, M, et al.
Cyhoeddwyd: (2014)

A simplified 4-site economical intradermal post-exposure rabies vaccine regimen: a randomised controlled comparison with standard methods
gan: Warrell, M, et al.
Cyhoeddwyd: (2008)

Innate immune responses to tuberculosis vaccines
gan: Matsumiya, M
Cyhoeddwyd: (2014)

Development of antimalarial human monoclonal antibodies against Plasmodium falciparum
gan: Wang, LT
Cyhoeddwyd: (2022)

Characterisation of T cells induced by candidate conserved region HIV-1 vaccines in healthy HIV-1/2 negative volunteers
gan: Ahmed, T, et al.
Cyhoeddwyd: (2014)

B cell response to pneumococcal vaccines
gan: Trück, J
Cyhoeddwyd: (2014)

The design and development of an HIV-1 vaccine to elicit a broadly neutralising antibody response
gan: Wan, L, et al.
Cyhoeddwyd: (2012)

B cell responses to conjugate and polysaccharide meningococcal vaccines
gan: Ramasamy, M
Cyhoeddwyd: (2012)

New approaches for improving the immunogenicity of modified vaccinia virus Ankara as a recombinant vaccine vector
gan: Alharbi, N
Cyhoeddwyd: (2014)

Genetics determinants of vaccine responses
gan: O'Connor, D
Cyhoeddwyd: (2014)

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations
gan: Hanekom, W, et al.
Cyhoeddwyd: (2008)

HIV-specific interleukin-10 responses and immune modulation
gan: Clutton, G
Cyhoeddwyd: (2012)

The role of antigen in the maintenance and localisation of CD8+ T-cells in the context of liver stage malaria
gan: Gola, A
Cyhoeddwyd: (2018)

Assessment of novel liver-stage vaccines using transgenic rodent malaria parasites
gan: Salman, AM
Cyhoeddwyd: (2014)

Antibody-based HIV-1 vaccines: recent developments and future directions
gan: Montefiori, D, et al.
Cyhoeddwyd: (2007)

Evaluation of immune correlates to TB vaccines
gan: Marsay, L
Cyhoeddwyd: (2011)

T-cell receptor (TCR) usage in HIV-2 infection
gan: Moysi, E
Cyhoeddwyd: (2012)

Identifying genetic determinants of impaired PfEMP1 export in Plasmodium falciparum-infected erythrocytes
gan: Neal, AT
Cyhoeddwyd: (2014)

Discovery of a conserved Plasmodium antigen on the surface of malaria-infected red blood cells
gan: Oteng, EK
Cyhoeddwyd: (2013)

Novel adenoviral vectored vaccines and the implications of viral diversity in therapeutic strategies against Hepatitis C Virus infection
gan: Kelly, C
Cyhoeddwyd: (2013)

Control of typhoid fever: evaluating herd protection through public health use of typhoid VI polysaccharide vaccine
gan: Ochiai, R
Cyhoeddwyd: (2011)

Assessment of anti-merozoite antibody function in the context of blood-stage malaria vaccine development
gan: Llewellyn, D
Cyhoeddwyd: (2014)

Refocusing antibody responses by chemical modification of vaccine antigens
gan: Schiffner, T
Cyhoeddwyd: (2014)

Effect of hemoglobins S and C on the in vivo expression and immune recognition of Plasmodium falciparum erythrocyte membrane protein 1 variants in Malian children
gan: Beaudry, J
Cyhoeddwyd: (2012)

Evaluation of the immunological mechanisms induced by mycobacteria and the potential effect this may have on immunity induced by tuberculosis vaccines
gan: Poyntz, HC
Cyhoeddwyd: (2012)