Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules.

In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and am...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Dzhambazov, B, Nandakumar, K, Kihlberg, J, Fugger, L, Holmdahl, R, Vestberg, M
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2006