Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules.

In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and am...

全面介绍

书目详细资料
Main Authors: Dzhambazov, B, Nandakumar, K, Kihlberg, J, Fugger, L, Holmdahl, R, Vestberg, M
格式: Journal article
语言:English
出版: 2006