Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules.
In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and am...
Κύριοι συγγραφείς: | , , , , , |
---|---|
Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2006
|