The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombination and protects DNA replication forks from attrition. BRCA1 partners with BRCA1-associated RING domain protein 1 (BARD1) and other tumour suppressor protei...

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Detalhes bibliográficos
Principais autores: Tarsounas, M, Sung, P
Formato: Journal article
Idioma:English
Publicado em: Nature Research 2020