Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors
Development of selective kinase inhibitors remains a challenge due to considerable amino acid sequence similarity among family members particularly in the ATP binding site. Targeting the activation loop might offer improved inhibitor selectivity since this region of kinases is less conserved. Howeve...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2018
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