Genome-wide genetic screening with chemically-mutagenized haploid embryonic stem cells
In model organisms, classical genetic screening via random mutagenesis provides key insights into the molecular bases of genetic interactions, helping defining synthetic-lethality, synthetic-viability and drug-resistance mechanisms. The limited genetic tractability of diploid mammalian cells, howeve...
| Main Authors: | , , , , , , , , |
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| Formato: | Journal article |
| Publicado: |
Nature Publishing Group
2016
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