Modulation of T-regulatory cells by small molecules: potential therapy for GvHD

Modulation of T-regulatory cells by small molecules: potential therapy for GvHD

Allogeneic haematopoietic stem cell transplantation (alloHSCT) is often curative for patients suffering from blood cancers. Nonetheless, significant morbidity and mortality are still prevalent. One major complication is graft versus host disease (GvHD) which occurs in 30-70% of patients. In this dis...

Полное описание

Библиографические подробности
Главный автор:	Leuschner, U
Другие авторы:	Roberts, D
Формат:	Диссертация
Язык:	English
Опубликовано:	2021

Схожие документы

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation
по: Mauro Di Ianni, и др.
Опубликовано: (2024-01-01)

The Role of Bacteria and Pattern Recognition Receptors in GvHD
по: E. Holler, и др.
Опубликовано: (2010-01-01)

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells
по: Haroon Shaikh, и др.
Опубликовано: (2022-11-01)

Bone marrow GvHD after allogeneic hematopoietic stem cell transplantation
по: Martin eSzyska, и др.
Опубликовано: (2016-03-01)

Immunometabolic Therapeutic Targets of Graft-versus-Host Disease (GvHD)
по: Kudakwashe Mhandire, и др.
Опубликовано: (2021-10-01)

Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis
по: Shai eYarkoni, и др.
Опубликовано: (2014-05-01)

Effect of the YCD3-1 Anti-Mouse Monoclonal on Murine GvHD
по: James P. Okunewick, и др.
Опубликовано: (1993-07-01)

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
по: Satish Ranjan, и др.
Опубликовано: (2017-08-01)

Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions
по: Seyed Mostafa Monzavi, и др.
Опубликовано: (2022-08-01)

Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD
по: Jongbok Lee, и др.
Опубликовано: (2025-01-01)

In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation.
по: Kottaridis, P, и др.
Опубликовано: (2001)

Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers
по: Ines Bojanic, и др.
Опубликовано: (2023-02-01)

Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy
по: Regina Jitschin, и др.
Опубликовано: (2023-03-01)

The role of animal models in the study of hematopoietic stem cell transplantation and GvHD: A historical overview.
по: Margherita Boieri, и др.
Опубликовано: (2016-08-01)

Campath 1 H "in the bag" is an effective method of GvHD prevention in allogeneic stem cell transplantation.
по: Potter, M, и др.
Опубликовано: (2000)

HSCT with Mismatched Unrelated Donors (MMUD): A Comparison of Different Platforms for GvHD Prophylaxis
по: Massimo Berger, и др.
Опубликовано: (2022-02-01)

Correction to: Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
по: Roberto Crocchiolo, и др.
Опубликовано: (2021-03-01)

Quality of life of patients with graft-versus-host disease (GvHD) post-hematopoietic stem cell transplantation
по: Sibéli de Fátima Ferraz Simão Proença, и др.

The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD following Hematopoietic Stem Cell Transplantation
по: Seyed Asadollah Mousavi, и др.
Опубликовано: (2016-12-01)

Immunomonitoring of MSC-Treated GvHD Patients Reveals Only Moderate Potential for Response Prediction but Indicates Treatment Safety
по: Joni Keto, и др.
Опубликовано: (2018-06-01)

Effective Extracorporeal Photopheresis of Patients with Transplantation Induced Acute Intestinal GvHD and Bronchiolitis Obliterans Syndrome
по: Robin Reschke, и др.
Опубликовано: (2022-08-01)

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition
по: Jaeyoon Ryu, и др.
Опубликовано: (2020-06-01)

Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide
по: Raffaella Greco, и др.
Опубликовано: (2019-10-01)

Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation
по: Hemn Mohammadpour, и др.
Опубликовано: (2023-03-01)

Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers
по: Yan-Ruide Li, и др.
Опубликовано: (2022-09-01)

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.
по: Mohammad S Hossain, и др.
Опубликовано: (2017-01-01)

Extracorporeal Photopheresis (ECP) and the Potential of Novel Biomarkers in Optimizing Management of Acute and Chronic Graft vs. Host Disease (GvHD)
по: Matthew Mankarious, и др.
Опубликовано: (2020-01-01)

IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model
по: Cuiping Zhang, и др.
Опубликовано: (2021-11-01)

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics
по: Sakhila Ghimire, и др.
Опубликовано: (2021-10-01)

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD
по: Sybille Landwehr-Kenzel, и др.
Опубликовано: (2021-10-01)

18F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)
по: Wolfgang Roll, и др.
Опубликовано: (2021-09-01)

HLA and Non-HLA Factors for Donor Selection in Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide GvHD Prophylaxis
по: Hiroko Shike, и др.
Опубликовано: (2024-12-01)

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD
по: Weijia Zhao, и др.
Опубликовано: (2023-08-01)

In marrow aplasia reduced-intensity conditioning and T-cell depletion of cytokine mobilised stem cells provides good engraftment without GvHD
по: Novitzky, N, и др.
Опубликовано: (2006)

Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD
по: Kati Hyvärinen, и др.
Опубликовано: (2020-02-01)

Regulatory T Cells in GVHD Therapy
по: Wen-wen Guo, и др.
Опубликовано: (2021-06-01)

Antibiotic use and ileocolonic immune cells in patients receiving fecal microbiota transplantation for refractory intestinal GvHD: a prospective cohort study
по: Walter Spindelboeck, и др.
Опубликовано: (2021-12-01)

Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells
по: Uwe Thiel, и др.
Опубликовано: (2017-05-01)

Visual and ocular surface benefits of mini-scleral contact lenses in patients with chronic ocular graft-versus-host disease (GvHD)
по: Philip Keye, и др.
Опубликовано: (2024-10-01)

Decreased Plasma Level of Cytokeratin 20 (KRT20) Is Indicative of the Emergence and Severity of Acute GvHD Irrespective to the Type of Organ Involvement
по: Nikolett Lupsa, и др.
Опубликовано: (2022-02-01)