Modulation of T-regulatory cells by small molecules: potential therapy for GvHD

Modulation of T-regulatory cells by small molecules: potential therapy for GvHD

Allogeneic haematopoietic stem cell transplantation (alloHSCT) is often curative for patients suffering from blood cancers. Nonetheless, significant morbidity and mortality are still prevalent. One major complication is graft versus host disease (GvHD) which occurs in 30-70% of patients. In this dis...

Bibliografske podrobnosti
Glavni avtor:	Leuschner, U
Drugi avtorji:	Roberts, D
Format:	Thesis
Jezik:	English
Izdano:	2021

Podobne knjige/članki

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation
od: Mauro Di Ianni, et al.
Izdano: (2024-01-01)

The Role of Bacteria and Pattern Recognition Receptors in GvHD
od: E. Holler, et al.
Izdano: (2010-01-01)

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells
od: Haroon Shaikh, et al.
Izdano: (2022-11-01)

Bone marrow GvHD after allogeneic hematopoietic stem cell transplantation
od: Martin eSzyska, et al.
Izdano: (2016-03-01)

Immunometabolic Therapeutic Targets of Graft-versus-Host Disease (GvHD)
od: Kudakwashe Mhandire, et al.
Izdano: (2021-10-01)

Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis
od: Shai eYarkoni, et al.
Izdano: (2014-05-01)

Effect of the YCD3-1 Anti-Mouse Monoclonal on Murine GvHD
od: James P. Okunewick, et al.
Izdano: (1993-07-01)

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
od: Satish Ranjan, et al.
Izdano: (2017-08-01)

Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions
od: Seyed Mostafa Monzavi, et al.
Izdano: (2022-08-01)

Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD
od: Jongbok Lee, et al.
Izdano: (2025-01-01)

In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation.
od: Kottaridis, P, et al.
Izdano: (2001)

Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers
od: Ines Bojanic, et al.
Izdano: (2023-02-01)

Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy
od: Regina Jitschin, et al.
Izdano: (2023-03-01)

The role of animal models in the study of hematopoietic stem cell transplantation and GvHD: A historical overview.
od: Margherita Boieri, et al.
Izdano: (2016-08-01)

Campath 1 H "in the bag" is an effective method of GvHD prevention in allogeneic stem cell transplantation.
od: Potter, M, et al.
Izdano: (2000)

HSCT with Mismatched Unrelated Donors (MMUD): A Comparison of Different Platforms for GvHD Prophylaxis
od: Massimo Berger, et al.
Izdano: (2022-02-01)

Correction to: Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
od: Roberto Crocchiolo, et al.
Izdano: (2021-03-01)

Quality of life of patients with graft-versus-host disease (GvHD) post-hematopoietic stem cell transplantation
od: Sibéli de Fátima Ferraz Simão Proença, et al.

The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD following Hematopoietic Stem Cell Transplantation
od: Seyed Asadollah Mousavi, et al.
Izdano: (2016-12-01)

Immunomonitoring of MSC-Treated GvHD Patients Reveals Only Moderate Potential for Response Prediction but Indicates Treatment Safety
od: Joni Keto, et al.
Izdano: (2018-06-01)

Effective Extracorporeal Photopheresis of Patients with Transplantation Induced Acute Intestinal GvHD and Bronchiolitis Obliterans Syndrome
od: Robin Reschke, et al.
Izdano: (2022-08-01)

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition
od: Jaeyoon Ryu, et al.
Izdano: (2020-06-01)

Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide
od: Raffaella Greco, et al.
Izdano: (2019-10-01)

Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation
od: Hemn Mohammadpour, et al.
Izdano: (2023-03-01)

Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers
od: Yan-Ruide Li, et al.
Izdano: (2022-09-01)

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients.
od: Mohammad S Hossain, et al.
Izdano: (2017-01-01)

Extracorporeal Photopheresis (ECP) and the Potential of Novel Biomarkers in Optimizing Management of Acute and Chronic Graft vs. Host Disease (GvHD)
od: Matthew Mankarious, et al.
Izdano: (2020-01-01)

IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model
od: Cuiping Zhang, et al.
Izdano: (2021-11-01)

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics
od: Sakhila Ghimire, et al.
Izdano: (2021-10-01)

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD
od: Sybille Landwehr-Kenzel, et al.
Izdano: (2021-10-01)

18F-FDG-PET-MRI for the assessment of acute intestinal graft-versus-host-disease (GvHD)
od: Wolfgang Roll, et al.
Izdano: (2021-09-01)

HLA and Non-HLA Factors for Donor Selection in Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide GvHD Prophylaxis
od: Hiroko Shike, et al.
Izdano: (2024-12-01)

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD
od: Weijia Zhao, et al.
Izdano: (2023-08-01)

In marrow aplasia reduced-intensity conditioning and T-cell depletion of cytokine mobilised stem cells provides good engraftment without GvHD
od: Novitzky, N, et al.
Izdano: (2006)

Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD
od: Kati Hyvärinen, et al.
Izdano: (2020-02-01)

Regulatory T Cells in GVHD Therapy
od: Wen-wen Guo, et al.
Izdano: (2021-06-01)

Antibiotic use and ileocolonic immune cells in patients receiving fecal microbiota transplantation for refractory intestinal GvHD: a prospective cohort study
od: Walter Spindelboeck, et al.
Izdano: (2021-12-01)

Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A*02:01-specific allorestricted T cell receptor transgenic T cells
od: Uwe Thiel, et al.
Izdano: (2017-05-01)

Visual and ocular surface benefits of mini-scleral contact lenses in patients with chronic ocular graft-versus-host disease (GvHD)
od: Philip Keye, et al.
Izdano: (2024-10-01)

Decreased Plasma Level of Cytokeratin 20 (KRT20) Is Indicative of the Emergence and Severity of Acute GvHD Irrespective to the Type of Organ Involvement
od: Nikolett Lupsa, et al.
Izdano: (2022-02-01)