The crystal structure of IgE Fc reveals an asymmetrically bent conformation.

The crystal structure of IgE Fc reveals an asymmetrically bent conformation.

The distinguishing structural feature of immunoglobulin E (IgE), the antibody responsible for allergic hypersensitivity, is the C epsilon 2 domain pair that replaces the hinge region of IgG. The crystal structure of the IgE Fc (constant fragment) at a 2.6-A resolution has revealed these domains. The...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Wan, T, Beavil, R, Fabiane, S, Beavil, A, Sohi, M, Keown, M, Young, R, Henry, A, Owens, R, Gould, H, Sutton, B
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2002

समान संसाधन

Structural basis of the IgE-Fc epsilon RI interaction.
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