Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3

Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3

<p>Many tumour causing proteins, such as those expressed after chromosomal translocations or from point mutations, are intracellular and are not enzymes <em>per se</em> amenable to conventional drug targeting. We previously demonstrated an approach (<u>A</u>ntibody-anti...

書誌詳細
主要な著者:	Chambers, J, Brend, T, Rabbitts, T
フォーマット:	Journal article
言語:	English
出版事項:	Nature Research 2019

類似資料

Intracellular antibody-caspase-mediated cell killing: an approach for application in cancer therapy.
著者:: Tse, E, 等
出版事項: (2000)

Intracellular antibody capture (IAC) methods for single domain antibodies.
著者:: Tanaka, T, 等
出版事項: (2012)

Cancer cell killing using engineered intracellular antibody fragments
著者:: Chambers, J
出版事項: (2018)

Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies.
著者:: Tanaka, T, 等
出版事項: (2003)

Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture.
著者:: Tanaka, T, 等
出版事項: (2010)

The selection of single-domain antibody fragments (iDAbs) by intracellular antibody capture in yeast
著者:: Rabbitts, T, 等
出版事項: (2018)

Selection of complementary single-variable domains for building monoclonal antibodies to native proteins.
著者:: Tanaka, T, 等
出版事項: (2009)

Functional intracellular antibody fragments do not require invariant intra-domain disulfide bonds.
著者:: Tanaka, T, 等
出版事項: (2008)

Isolation of antigen-specific intracellular antibody fragments as single chain Fv for use in mammalian cells.
著者:: Tse, E, 等
出版事項: (2002)

Intracellular Antibodies for Drug Discovery and as Drugs of the Future
著者:: T. H. Rabbitts
出版事項: (2023-03-01)

Intracellular antibodies and challenges facing their use as therapeutic agents.
著者:: Lobato, M, 等
出版事項: (2003)

Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain.
著者:: Tanaka, T, 等
出版事項: (2011)

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein.
著者:: Tse, E, 等
出版事項: (2002)

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells
著者:: Wei Li, 等
出版事項: (2017-08-01)

Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules.
著者:: Lobato, M, 等
出版事項: (2004)

Intracellular antibodies and cancer: new technologies offer therapeutic opportunities.
著者:: Pérez-Martínez, D, 等
出版事項: (2010)

An in vitro model of antibody-enhanced killing of the intracellular parasite Leishmania amazonensis.
著者:: Katherine N Gibson-Corley, 等
出版事項: (2014-01-01)

De novo production of diverse intracellular antibody libraries.
著者:: Tanaka, T, 等
出版事項: (2003)

Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions.
著者:: Zhang, J, 等
出版事項: (2014)

Therapeutic antibodies against intracellular tumor antigens
著者:: Trenevska, I, 等
出版事項: (2017)

Therapeutic Antibodies against Intracellular Tumor Antigens
著者:: Iva Trenevska, 等
出版事項: (2017-08-01)

Covering All the Bases: Complementary MR1 Antigen Presentation Pathways Sample Diverse Antigens and Intracellular Compartments
著者:: Corinna Kulicke, 等
出版事項: (2020-09-01)

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein
著者:: Bao, L, 等
出版事項: (2017)

Potent antitumor activity of a bispecific T-cell engager antibody targeting the intracellular antigen KRAS G12V
著者:: Changchang Lu, 等
出版事項: (2024-05-01)

An Inside Job: Applications of Intracellular Single Domain Antibodies
著者:: Eline Soetens, 等
出版事項: (2020-12-01)

DNA‐Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing
著者:: Liqiang Pan, 等
出版事項: (2020-01-01)

A Cell-based Screening Method Using an Intracellular Antibody for Discovering Small Molecules Targeting Hard-to-drug Proteins
著者:: Nicolas Bery, 等
出版事項: (2022-02-01)

Bacteriophage infection and killing of intracellular Mycobacterium abscessus
著者:: Alan A. Schmalstig, 等
出版事項: (2024-01-01)

LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
著者:: Ruggero, K, 等
出版事項: (2016)

LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
著者:: Ruggero, K, 等
出版事項: (2016)

Means of intracellular communication: touching, kissing, fusing
著者:: Anne Spang
出版事項: (2021-04-01)

Monocytes in inflammatory bowel disease: phagocytosis and intracellular killing.
著者:: Mee, A, 等
出版事項: (1980)

The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes
著者:: Ewa Jończyk-Matysiak, 等
出版事項: (2015-01-01)

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.
著者:: Tanaka, T, 等
出版事項: (2007)

Successful 'passive transfer' of paraneoplastic stiff person syndrome with antibodies to an intracellular antigen.
著者:: Vincent, A
出版事項: (2010)

Caspase-5: Structure, Pro-Inflammatory Activity and Evolution
著者:: Leopold Eckhart, 等
出版事項: (2024-04-01)

Chromosomal translocation products engender new intracellular therapeutic technologies.
著者:: Rabbitts, T, 等
出版事項: (2003)

241 Dual targeting liver cancer by GPC3 CAR-T cells secreting a bispecific T cell engager antibody for an intracellular tumor antigen AFP
著者:: Chao Cheng, 等
出版事項: (2023-11-01)

Bosutinib stimulates macrophage survival, phagocytosis, and intracellular killing of bacteria
著者:: da Silva, Ronni A. G., 等
出版事項: (2024)

Fusing Antigens and Adjuvants into Traceless Nanogels
著者:: Bruno G. De Geest
出版事項: (2020-03-01)