The role of the transcription factor BRN2 in melanoma

The role of the transcription factor BRN2 in melanoma

<p>Expression of the POU-domain transcription factor BRN2 is crucial for the developing brain and drives proliferation and invasiveness in cancers of neural crest origin including melanoma. However, our understanding of BRN2 function and how its behaviour is modulated remains incomplete. We th...

Полное описание

Библиографические подробности
Главный автор:	Herbert, K
Другие авторы:	Goding, C
Формат:	Диссертация
Опубликовано:	2018

Схожие документы

The Brn-2 transcription factor links activated BRAF to melanoma proliferation.
по: Goodall, J, и др.
Опубликовано: (2004)

Regulation of MITF and Brn2 in melanoma
по: Agkatsev, S
Опубликовано: (2014)

Targeting Neuronal Transcription Factor BRN2 in Neuroendocrine Tumors
по: Ravi Munuganti, и др.
Опубликовано: (2019-08-01)

The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
по: Eisen, T, и др.
Опубликовано: (1995)

Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells.
по: Goodall, J, и др.
Опубликовано: (2008)

BRN2 is a non-canonical melanoma tumor-suppressor
по: Hamm, M, и др.
Опубликовано: (2021)

BRN2 is a non-canonical melanoma tumor-suppressor
по: Michael Hamm, и др.
Опубликовано: (2021-06-01)

The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival
по: Tobias Hohenauer, и др.
Опубликовано: (2013-05-01)

Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion
по: Soraia Barão, и др.
Опубликовано: (2024-09-01)

Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.
по: Goodall, J, и др.
Опубликовано: (2004)

Brn2 is a transcription factor regulating keratinocyte differentiation with a possible role in the pathogenesis of lichen planus.
по: Ge Shi, и др.
Опубликовано: (2010-01-01)

Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception
по: Liudmila V. Spirina, и др.
Опубликовано: (2019-08-01)

A phosphatidylinositol 3-kinase-Pax3 axis regulates Brn-2 expression in melanoma.
по: Bonvin, E, и др.
Опубликовано: (2012)

BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
по: Herbert, K, и др.
Опубликовано: (2019)

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF
по: Mitchell E. Fane, и др.
Опубликовано: (2017-02-01)

The two activation domains of the Brn-3a transcription factor have distinct functional properties
по: Begbie, J, и др.
Опубликовано: (1997)

Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification.
по: Melody Shi, и др.
Опубликовано: (2013-01-01)

NFIB mediates BRN2 driven melanoma cell migration and invasion through regulation of EZH2 and MITF
по: Fane, M, и др.
Опубликовано: (2017)

Reciprocal regulation of BRN2 and NOTCH1/2 signaling synergistically drives melanoma cell migration and invasion
по: Fane, M, и др.
Опубликовано: (2021)

Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination.
по: Pinner, S, и др.
Опубликовано: (2009)

Importance of BRN2 phosphorylation for melanocyte migration
по: Berlin, I, и др.
Опубликовано: (2011)

TRANSCRIPTION FACTOR BRN-3α AND PROSTATE CANCER, RELATION WITH HORMONE RECEPTORS AND AKT/M-TOR SIGNALING PATHWAY ACTIVATION
по: L. V. Spirina, и др.
Опубликовано: (2018-03-01)

NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons.
по: Wyatt, S, и др.
Опубликовано: (1998)

Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development.
по: Kira Orlovsky, и др.
Опубликовано: (2024-12-01)

Crystal structure of 5-bromopyrimidine, C4H3BrN2
по: Staples Richard J., и др.
Опубликовано: (2007-09-01)

Rb induces a proliferative arrest and curtails <it>Brn-2 </it>expression in retinoblastoma cells
по: Abramson David H, и др.
Опубликовано: (2006-12-01)

Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways
по: Vaishaali Yogendran, и др.
Опубликовано: (2023-11-01)

BRN2 phosphorylation regulates melanoblast migration and proliferation through PAX3 and MITF-M
по: Berlin, I, и др.
Опубликовано: (2011)

Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer
по: Ahmed Nuzhat, и др.
Опубликовано: (2010-07-01)

Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation.
по: Berlin, I, и др.
Опубликовано: (2012)

Crystal structure of 2-bromobenzoic acid hydrazide, C7H7BrN2O
по: Zareef M., и др.
Опубликовано: (2006-04-01)

Crystal structure of N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2- methoxybenzohydrazide monohydrate, C16H15BrN2O4·H2O, C16H17BrN2O5
по: Liang Dan-Xia, и др.
Опубликовано: (2012-12-01)

Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival
по: Cheng Tan, и др.
Опубликовано: (2014-01-01)

Crystal structure of 3-(2-bromophenyl)-1,1-dimethylthiourea, C9H11BrN2S
по: El-Hiti Gamal A., и др.
Опубликовано: (2017-01-01)

Lama2 And Samsn1 Mediate the Effects of Brn4 on Hippocampal Neural Stem Cell Proliferation and Differentiation
по: Lei Zhang, и др.
Опубликовано: (2023-01-01)

ClBRN1 from Chrysanthemum lavandulifolium enhances the stress resistance of transgenic Arabidopsis
по: Yanxi Li, и др.
Опубликовано: (2024-12-01)

ZEB1 transcription factor promotes immune escape in melanoma
по: Christophe Caux, и др.
Опубликовано: (2022-03-01)

Transcription regulation in melanocytes and melanoma
по: Goding, C
Опубликовано: (2008)

Transcriptional control of phenotype in melanoma
по: Mosteo López, L
Опубликовано: (2019)

Crystal structure of N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-4- nitrobenzohydrazide monohydrate, C15H12BrN3O5·H2O, C15H14BrN3O6
по: Hong Zhe, и др.
Опубликовано: (2012-12-01)