Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite (Plasmodium falciparum) or other pathogen DNA. As P. falciparum infects red blood cells and not leukocytes, how parasite DNA reaches such host cytosolic DNA sensors in immune cells is unclear. Here we show that...

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Bibliografiska uppgifter
Huvudupphovsmän: Sisquella, X, Ofir-Birin, Y, Pimentel, M, Cheng, L, Abou Karam, P, Sampaio, N, Penington, J, Connolly, D, Giladi, T, Scicluna, B, Sharples, R, Waltmann, A, Avni, D, Schwartz, E, Schofield, L, Porat, Z, Hansen, D, Papenfuss, A, Eriksson, E, Gerlic, M, Hill, A, Bowie, A, Regev-Rudzki, N
Materialtyp: Journal article
Språk:English
Publicerad: Nature Publishing Group 2017

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