A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce the type 2 cytokines IL-5 and IL-13. Skin-derived ILC2s express the IL-33 rece...

书目详细资料
Main Authors:	Salimi, M, Barlow, J, Saunders, S, Xue, L, Gutowska-Owsiak, D, Wang, X, Huang, L, Johnson, D, Scanlon, S, McKenzie, A, Fallon, P, Ogg, G
格式:	Journal article
语言:	English
出版:	Rockefeller University Press. 2013

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