Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.

Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.

The imino sugar N-butyldeoxynojirimycin (NB-DNJ) is a glucose analogue which inhibits the glycoprotein N-glycan processing enzymes alpha-glucosidases I and II and the ceramide glucosyltransferase that catalyses the first step of glycosphingolipid biosynthesis. This and other N-alkylated DNJ compound...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andersson, U, Reinkensmeier, G, Butters, T, Dwek, R, Platt, F
Formato:	Journal article
Lenguaje:	English
Publicado:	2004

Ejemplares similares

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
por: Butters, T, et al.
Publicado: (2005)

Therapeutic applications of imino sugars in lysosomal storage disorders.
por: Butters, T, et al.
Publicado: (2003)

Imino sugar therapy for type 1 Gaucher disease.
por: Priestman, D, et al.
Publicado: (2000)

Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation.
por: Mellor, H, et al.
Publicado: (2003)

Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis
por: Butters, T, et al.
Publicado: (2000)

Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells.
por: Boomkamp, S, et al.
Publicado: (2010)

Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.
por: Mehta, A, et al.
Publicado: (2001)

High-performance cation-exchange chromatography and pulsed amperometric detection for the separation, detection, and quantitation of N-alkylated imino sugars in biological samples.
por: Mellor, H, et al.
Publicado: (2000)

N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo.
por: Andersson, U, et al.
Publicado: (2000)

Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception.
por: van der Spoel, A, et al.
Publicado: (2002)

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents
por: Zitzmann, N, et al.
Publicado: (1999)

Alkylated imino sugars, reversible male infertility-inducing agents, do not change the genetic integrity of male mouse germ cells, despite severe deformities of spermatozoal structures.
por: Suganuma, R, et al.
Publicado: (2004)

SYNTHESIS OF 1,5-DIDEOXY-3-O-(ALPHA-D-MANNOPYRANOSYL)-1,5-IMINO-D-MANNITOL AND 1,5-DIDEOXY-3-O-(ALPHA-D-GLUCOPYRANOSYL)-1,5-IMINO-D-MANNITOL - POWERFUL INHIBITORS OF ENDOMANNOSIDASE
por: Ardron, H, et al.
Publicado: (1993)

Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities.
por: Suganuma, R, et al.
Publicado: (2005)

Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.
por: Butters, T, et al.
Publicado: (2000)

High-performance liquid chromatography analysis of ganglioside carbohydrates at the picomole level after ceramide glycanase digestion and fluorescent labeling with 2-aminobenzamide.
por: Wing, DR, et al.
Publicado: (2001)

Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.
por: van der Spoel, A, et al.
Publicado: (2008)

DISCOVERY OF A SELECTIVE LYSOSOMAL ALPHA-MANNOSIDASE INHIBITOR FROM AN IMINO-SUGAR LIBRARY
por: Chang, Y, et al.
Publicado: (2014)

Novel di-branched monosaccharides and imino sugars
por: Barker, K, et al.
Publicado: (2009)

2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol
por: Harding, C, et al.
Publicado: (2005)

New developments in treating glycosphingolipid storage diseases.
por: Platt, F, et al.
Publicado: (2005)

Substrate reduction therapy in mouse models of the glycosphingolipidoses.
por: Platt, F, et al.
Publicado: (2003)

Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
por: Norris-Cervetto, E, et al.
Publicado: (2004)

Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy.
por: Jonathan Zirin, et al.
Publicado: (2013-11-01)

2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol 0.33-hydrate
por: Harding, C, et al.
Publicado: (2005)

Inhibition of cell wall-associated enzymes in vitro and in vivo with sugar analogs.
por: Nagahashi, G, et al.
Publicado: (1990)

New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.
por: Butters, T, et al.
Publicado: (2003)

Iminosugar inhibitors for treating the lysosomal glycosphingolipidoses
por: Butters, T, et al.
Publicado: (2005)

Inhibition of membrane-associated viral replication
por: Block, T, et al.
Publicado: (2016)

Hexacosylidenecyclohexane inhibits enzymatic breakdown of dietary sugars and modulates glucose homeostasis
por: Kavishankar Gawli, et al.
Publicado: (2022-05-01)

Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.
por: Mellor, H, et al.
Publicado: (2004)

Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP
por: Maria A. Schumacher, et al.
Publicado: (2022-10-01)

The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise
por: Jørgen eJensen, et al.
Publicado: (2011-12-01)

Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate
por: Krulle, T, et al.
Publicado: (1997)

Human GM3 synthase deficiency: Autosomal recessive infantile onset symptomatic epilepsy syndrome.
por: Priestman, D, et al.
Publicado: (2004)

Human GM3 synthase deficiency: A novel form of hereditary childhood epilepsy
por: Priestman, D, et al.
Publicado: (2005)

Introduction
por: Dwek, R, et al.
Publicado: (2003)

Glycolipids in cell biology and medicine - Introduction
por: Dwek, R, et al.
Publicado: (2003)

Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides.
por: Mellor, H, et al.
Publicado: (2004)

Improved outcome of N-butyldeoxygalactonojirimycin-mediated substrate reduction therapy in a mouse model of Sandhoff disease.
por: Andersson, U, et al.
Publicado: (2004)