Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.

Several inwardly-rectifying (Kir) potassium channels (Kir1.1, Kir4.1 and Kir4.2) are characterised by their sensitivity to inhibition by intracellular H(+) within the physiological range. The mechanism by which these channels are regulated by intracellular pH has been the subject of intense scrutiny...

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Main Authors: Paynter, J, Shang, L, Bollepalli, M, Baukrowitz, T, Tucker, S
פורמט: Journal article
שפה:English
יצא לאור: 2010