Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

Women with polycystic ovary syndrome (PCOS) have high circulating androgens, thought to originate from ovaries and adrenals, and frequently suffer from the metabolic syndrome including obesity. However, serum androgens are positively associated with body mass index (BMI) not only in PCOS, but also i...

書誌詳細
主要な著者:	Quinkler, M, Sinha, B, Tomlinson, J, Bujalska, I, Stewart, P, Arlt, W
フォーマット:	Journal article
言語:	English
出版事項:	2004

類似資料

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.
著者:: Tomlinson, J, 等
出版事項: (2002)

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
著者:: Tomlinson, J, 等
出版事項: (2000)

11 beta-hydroxysteroid dehydrogenase type 1 in obese children
著者:: Wiegand, S, 等
出版事項: (2007)

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
著者:: Bujalska, I, 等
出版事項: (2006)

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.
著者:: Wiegand, S, 等
出版事項: (2007)

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.
著者:: Tomlinson, J, 等
出版事項: (2002)

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.
著者:: Stewart, P, 等
出版事項: (2002)

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.
著者:: Tomlinson, J, 等
出版事項: (2001)

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
著者:: Tomlinson, J, 等
出版事項: (2001)

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.
著者:: Bujalska, I, 等
出版事項: (2007)

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy.
著者:: Tomlinson, J, 等
出版事項: (2010)

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
著者:: Bujalska, I, 等
出版事項: (2005)

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.
著者:: Bujalska, I, 等
出版事項: (2002)

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
著者:: Lukacik, P, 等
出版事項: (2006)

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
著者:: Tomlinson, J, 等
出版事項: (2004)

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.
著者:: Tomlinson, J, 等
出版事項: (2004)

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.
著者:: Bujalska, I, 等
出版事項: (2008)

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
著者:: Draper, N, 等
出版事項: (2003)

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.
著者:: Tomlinson, J, 等
出版事項: (2003)

Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.
著者:: Oppermann, U, 等
出版事項: (1997)

Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase
著者:: Jose Antonio Mondragón Dr, 等
出版事項: (2021-10-01)

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.
著者:: Sinclair, A, 等
出版事項: (2007)

Effects of glucocorticoids on fat mass and the therapeutic potential of targeting II beta-hydroxysteroid dehydrogenase type I in obesity
著者:: Tomlinson, J
出版事項: (2009)

Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13
著者:: Shenping Liu, 等
出版事項: (2023-08-01)

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
著者:: Morgan, SA, 等
出版事項: (2009)

Cerebrospinal fluid production - A role for 11 beta-hydroxysteroid dehydrogenase type 1?
著者:: Rauz, S, 等
出版事項: (2004)

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.
著者:: Valsamakis, G, 等
出版事項: (2004)

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.
著者:: Swali, A, 等
出版事項: (2008)

Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.
著者:: Nordling, E, 等
出版事項: (2001)

Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors.
著者:: Korbonits, M, 等
出版事項: (2001)

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?
著者:: Stewart, P, 等
出版事項: (2009)

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.
著者:: Tomlinson, J, 等
出版事項: (2005)

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
著者:: Tomlinson, J, 等
出版事項: (2007)

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.
著者:: Morgan, SA, 等
出版事項: (2010)

Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
著者:: Stimson, R, 等
出版事項: (2009)

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
著者:: Tomlinson, J
出版事項: (2005)

A case of 17-beta-hydroxysteroid dehydrogenase deficiency type 3 in adult endocrinologist practice
著者:: N. V. Molashenko, 等
出版事項: (2023-05-01)

Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
著者:: Yoshimichi Takeda, 等
出版事項: (2024-03-01)

A novel genetically-obese rat model with elevated 11beta-hydroxysteroid dehydrogenase type 1 activity in subcutaneous adipose tissue
著者:: Giridharan Nappan V, 等
出版事項: (2010-11-01)

Increased central adiposity and decreased subcutaneous adipose tissue 11β‐hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance—A longitudinal cohort study
著者:: Crowley, R, 等
出版事項: (2019)