Statins bind to cardiac ryanodine receptor (RyR2) channels to alter opening frequency

Geahča maid

• Atorvastatin activates skeletal RyR1 channels: towards reducing statin side-effects
  Dahkki: Lindsay, C, et al.
  Almmustuhtton: (2018)
• Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform
  Dahkki: Venturi, E, et al.
  Almmustuhtton: (2017)
• Voltage-dependent modulation of cardiac ryanodine receptors (RyR2) by protamine.
  Dahkki: Paula L Diaz-Sylvester, et al.
  Almmustuhtton: (2009-12-01)
• Modelling the ATP binding site of RyR2 to rationalise ligand-induced gating behaviour
  Dahkki: Lindsay, C, et al.
  Almmustuhtton: (2019)
• Impaired ligand regulation of native RyR2 channels in the catecholaminergic polymorphic ventricular tachycardia mutation, RyR2-V2475F(+/−)
  Dahkki: Wilson, A, et al.
  Almmustuhtton: (2019)