Age and strain related aberrant Ca(2+) release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy
Patients with hypertrophic cardiomyopathy (HCM), particularly young adults, can die from arrhythmia but the mechanism underlying abnormal rhythm formation remains unknown. C57Bl6 x CBA/Ca mice carrying a cardiac actin (ACTC) E99K (Glu99Lys) mutation reproduce many aspects of human HCM including incr...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Physiological Society
2017
|