The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.
Chromosomal translocations are primary events in the development of leukemias, representing at least one genetic feature of the putative cancer stem cell. Studies of genes influenced by chromosomal translocations have yielded a vast amount of information about how cancer is initiated and maintained....
Κύριοι συγγραφείς: | Nam, C, Rabbitts, T |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2006
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
ανά: McCormack, M, κ.ά.
Έκδοση: (2003) -
Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.
ανά: Utpal P Davé, κ.ά.
Έκδοση: (2009-05-01) -
Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.
ανά: McCormack, M, κ.ά.
Έκδοση: (2004) -
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
ανά: McCormack, M, κ.ά.
Έκδοση: (2010) -
High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic leukemia
ανά: Lili Wu, κ.ά.
Έκδοση: (2015-06-01)