The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.
Chromosomal translocations are primary events in the development of leukemias, representing at least one genetic feature of the putative cancer stem cell. Studies of genes influenced by chromosomal translocations have yielded a vast amount of information about how cancer is initiated and maintained....
Main Authors: | Nam, C, Rabbitts, T |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2006
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פריטים דומים
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The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
מאת: McCormack, M, et al.
יצא לאור: (2003) -
Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.
מאת: Utpal P Davé, et al.
יצא לאור: (2009-05-01) -
Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.
מאת: McCormack, M, et al.
יצא לאור: (2004) -
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal.
מאת: McCormack, M, et al.
יצא לאור: (2010) -
High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic leukemia
מאת: Lili Wu, et al.
יצא לאור: (2015-06-01)