Tau exacerbates excitotoxic brain damage in an animal model of stroke

Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau-/-) mice are profoundly protected from excitotoxic brain damage and neurological deficits following experimental stroke, using a middle cerebr...

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Bibliographic Details
Main Authors: Bi, M, Gladbach, A, van Eersel, J, Ittner, A, Przybyla, M, van Hummel, A, Chua, S, Hoven, J, Lee, W, Müller, J, Parmar, J, Jonquieres, G, Stefen, H, Guccione, E, Fath, T, Housley, G, Klugmann, M, Ke, Y, Ittner, L
Format: Journal article
Language:English
Published: Springer Nature 2017