Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1–mediated endocytosis
Matrix protease activity is fundamental to developmental tissue patterning and remains influential in adult homeostasis. In cartilage, the principal matrix proteoglycan is aggrecan, the protease-mediated catabolism of which defines arthritis; however, the pathophysiologic mechanisms that drive aberr...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Published: |
Federation of American Society of Experimental Biology
2018
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