Developing inhibitors of bromodomain-histone interactions

Developing inhibitors of bromodomain-histone interactions

<p>Lysine acetylation is a widespread protein post-translational modification that influences diverse cellular processes. An association between acetylation of histone N-terminal tails and transcriptional activation has been recognised since the 1960s. However, it has only become apparent sinc...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Hewings, D
Rannpháirtithe:	Conway, S
Formáid:	Tráchtas
Teanga:	English
Foilsithe / Cruthaithe:	2014
Ábhair:	Chemical biology Physical Sciences Organic chemistry Organic synthesis Chemistry & allied sciences

Míreanna comhchosúla

Development of small molecule inhibitors of the bromodomain-histone interaction
de réir: Rooney, TPC
Foilsithe / Cruthaithe: (2014)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
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Palladium mediated allylic fluorination
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Aziridinations of tethered allenes
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Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
de réir: Poingdestre, SJ
Foilsithe / Cruthaithe: (2012)

Development of ligands to target bromodomain-histone interactions
de réir: Jennings, L
Foilsithe / Cruthaithe: (2015)

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
de réir: Hewings, D, et al.
Foilsithe / Cruthaithe: (2011)

Novel di-branched monosaccharides and imino sugars
de réir: Barker, K, et al.
Foilsithe / Cruthaithe: (2009)

The development of small molecule inhibitors of the essential Leishmania bromodomain LdBDF5
de réir: Carter, JL
Foilsithe / Cruthaithe: (2023)

Olefin metathesis for site-selective protein modification
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Phosphoramidite ligand design for the enantioselective conjugate addition of alkylzirconium reagents to enones
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Alkaloids from transannular iodoaminations
de réir: Brock, E
Foilsithe / Cruthaithe: (2012)

Palladium-catalysed cyclisations of bromoenynamides in the synthesis and applications of amidodienes
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Determining the structures of halogenated marine natural products by total synthesis
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Cation-controlled diastereo- and enantioselective synthesis of indolines: an autocatalytic process
de réir: Sharma, K
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Towards the total synthesis of calyciphylline A-type Daphniphyllum alkaloids
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Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
de réir: Kaka, N, et al.
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Palladium- and copper-catalysed heterocycle synthesis
de réir: Ball, C
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Synthesis and elaboration of heterocycles via palladium-catalyzed C-H functionalization
de réir: Gerelle, M
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Studies towards the stereoselective synthesis of alkenes
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Chiral cation-directed asymmetric 5-endo-trig cyclizations
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Design and synthesis of inositol phosphate-based probes
de réir: Slowey, A
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Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
de réir: Hodgson, D, et al.
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Asymmetric syntheses of β- and γ-amino acids
de réir: Zammit, C
Foilsithe / Cruthaithe: (2015)

Reactions of allenylpalladium intermediates in organic synthesis
de réir: Daniels, DSB
Foilsithe / Cruthaithe: (2013)

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
de réir: Donohoe, T, et al.
Foilsithe / Cruthaithe: (2011)

Transition metal catalysed C-C bond formation via C-H functionalisation
de réir: Truscott, FR
Foilsithe / Cruthaithe: (2012)

The synthesis and biology of iminosugars and their precursors
de réir: Ayers, B, et al.
Foilsithe / Cruthaithe: (2014)

Studies towards the total synthesis of manzamine A
de réir: Hawkins, A
Foilsithe / Cruthaithe: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
de réir: Cordonnier, M, et al.
Foilsithe / Cruthaithe: (2011)

Enantiorecognition phenomena in asymmetric synthesis
de réir: Yin, J, et al.
Foilsithe / Cruthaithe: (2011)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
de réir: Pattarakiat, Seankongsuk
Foilsithe / Cruthaithe: (2022)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
de réir: Rydzik, AM
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Asymmetric synthesis of piperidine alkaloids
de réir: Thomson, A, et al.
Foilsithe / Cruthaithe: (2012)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
de réir: Lenden, P
Foilsithe / Cruthaithe: (2011)

Synthesis of mono- and bicyclic azacycles via palladium- and ruthenium-catalysed enynamide cycloisomerisation
de réir: Walker, P, et al.
Foilsithe / Cruthaithe: (2014)

Halogen bonding interlocked host systems for recognition and sensing of anions
de réir: Mullaney, B, et al.
Foilsithe / Cruthaithe: (2014)

A glycopore for bacterial sensing
de réir: Shanley, SJ
Foilsithe / Cruthaithe: (2009)

Novel palladium-catalysed routes to aromatic heterocycles
de réir: Pilgrim, B, et al.
Foilsithe / Cruthaithe: (2013)

An ion-binding approach to asymmetric allylation reactions
de réir: Stovold, CP
Foilsithe / Cruthaithe: (2013)